The metabolic effects of acute (4 h) and prolonged (24 h) growth hormone excess at pathophysiological concentrations were studied by growth hormone administration to normal subjects with and without somatostatin induced insulin deficiency. Acute growth hormone excess produced mild hyperinsulinaemia,
Effects of growth hormone on insulin sensitivity and forearm metabolism in normal man
✍ Scribed by N. Møller; P. C. Butler; M. A. Antsiferov; K. G. M. M. Alberti
- Publisher
- Springer
- Year
- 1989
- Tongue
- English
- Weight
- 589 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0012-186X
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We infused growth hormone into normal subjects in doses that raised circulating hormone to levels (30-35 ng/ml) similar to those seen during stress. Growth hormone excess failed to alter fasting glucose and somatomedin concentrations. However, non-esterified fatty acids and ketones increased by 50%
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