A simple synthesis of γ and δ-keto α-amino acid derivatives
✍ Scribed by Norman Aubry; Raymond Plante; Robert Déziel
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- French
- Weight
- 115 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
## Abstract (__R__)‐(−)‐2‐Amino‐4‐fluorobutyric acid (4c) (32% ee) and six of its homologues 9 have been synthesized by diastereoselective alkylation (54–72% yield) of (__R__)‐(+)‐camphor‐based glycine ester imines 1 with 1‐bromo‐2‐fluoro‐alkanes 6, at low temperature, followed by deprotection. Sim
## Abstract Asymmetric alkylation of (__S__)‐Boc‐BMI (**1a**, BMI = 2‐__tert__‐butyl‐3‐methylimidazolidin‐4‐one) and its α‐methyl derivative **1b** with 2‐fluoroallyl tosylate, subsequent mild acidic deprotection of the products **2a** and **2b**, and basic hydrolysis of the thus formed __N__‐methy
## Abstract For Abstract see ChemInform Abstract in Full Text.