A convenient synthesis of geiparvarin
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Takashi Sakai; Hiroshi Ito; Akitoshi Yamawaki; Akira Takeda
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Article
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1984
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Elsevier Science
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French
⚖ 137 KB
Acylation of 3-methyl-2,3-bis(trimethylsiloxy)-1-butene (PhLi) with (E)-2-methyl-2-butenoyl chloride gives the corresponding 3(2H)-furanone derivative, which can be readily converted to the naturally occurring antitumor agent Geiparvarin by two steps. Recently, considerable attention has been attrac