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A simple synthesis of geiparvarin

✍ Scribed by Chen Kau-Ming; Madeleine M. Joullié


Book ID
104229983
Publisher
Elsevier Science
Year
1984
Tongue
French
Weight
108 KB
Volume
25
Category
Article
ISSN
0040-4039

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A convenient synthesis of geiparvarin
✍ Takashi Sakai; Hiroshi Ito; Akitoshi Yamawaki; Akira Takeda 📂 Article 📅 1984 🏛 Elsevier Science 🌐 French ⚖ 137 KB

Acylation of 3-methyl-2,3-bis(trimethylsiloxy)-1-butene (PhLi) with (E)-2-methyl-2-butenoyl chloride gives the corresponding 3(2H)-furanone derivative, which can be readily converted to the naturally occurring antitumor agent Geiparvarin by two steps. Recently, considerable attention has been attrac