A simple strategy for the synthesis of hydroxyethylene dipeptide isostere from D-glucose
โ Scribed by T.K. Chakraborty; K. Azhar Hussain; D. Thippeswamy
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- French
- Weight
- 557 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0040-4020
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๐ SIMILAR VOLUMES
2S,4S,5S)-5-Amino-6-cyclohexyl-4-hydroxy-2-~sopropyl hexanoic acid lactone (5) was synthesized from x,4,6-tri-0-acetyl-D-glucal in an efficient manner.
Abatraot: An efficient and hiihly stereoselective route for preparing hydroxyethylene dipeptide isosteres from a-N,Ndibenzylamino ketones has been developed. In the last few years hydroxyethylene dipeptide isosteres ("peptide mimics') have generated considerable interest in the scientific community
Two stereoisomers of the title compound have been synthesized from the methyl ester of N-Boc L-valine. The aminoester was initially converted into an a%-amino a,b-unsaturated ketone via a phosphonoketone and a Horner-Emmons olefination with acetaldehyde. Hydrocyanation of the enone with diethylalumi
Two sample approaches to an ammo-alcohol isostere of proteolytrcally-cleavable dipeptrde sequences are descrrbed; this isostere is incorporated into stereochemically-defined tetrapeptlde analogues. We1 and others2 have shown that replacement of the cleavable amrde bond of appropriate peptide substra