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A simple protocol for the synthesis of a piperidine-2,6-dione framework from Baylis–Hillman adducts

✍ Scribed by Deevi Basavaiah; Dandamudi V. Lenin; Badugu Devendar

Publisher: Elsevier Science
Year: 2009
Tongue: French
Weight: 668 KB
Volume: 50
Category: Article
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2009.03.038

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✦ Synopsis

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## Abstract A facile, convenient, and one‐pot multi‐step synthesis of substituted piperidin‐2‐ones from the __Baylis__–__Hillman__ alcohols derived from various aldehydes and acrylonitrile, involving __Johnson__–__Claisen__ rearrangement, reduction of an __α__,__β__‐unsaturated nitrile moiety into