A simple one-pot synthesis of functionalised 6-(indol-3-yl)-2,2′-bipyridine derivatives via multi-component reaction under neat condition

✍ Scribed by Prakasam Thirumurugan; Paramasivan T. Perumal

• Publisher: Elsevier Science
• Year: 2009
• Tongue: French
• Weight: 389 KB
• Volume: 50
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2009.04.121

✦ Synopsis

2,2 0 -bipyridine Multi-component reaction 3-Cyanoacetyl indole Neat condition 2,2 0 -Bipyridine Microwave irradiation Cinnamils a b s t r a c t A series of 4-aryl-6-(1H-indol-3-yl)-2,2-bipyridine-5-carbonitrile derivatives were synthesized via a onepot multi-component reaction of aromatic aldehydes, 3-(cyanoacetyl)indole and 2-acetyl pyridine in ammonium acetate by conventional heating and microwave irradiation under solvent-free condition. Also a series of 6,6 0 -di(1H-indol-3-yl)-4,4 0 -diaryl-2,2 0 -bipyridine-5,5 0 -dicarbonitrile derivatives were synthesized using cinnamils, 3-(cyanoacetyl)indole and ammonium acetate. The methodology affords high yields of product at short reaction time.