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A simple one pot procedure for the generation of homoallylic alcohols from acetals and amino acetals

✍ Scribed by Adam McCluskey; Debra M Mayer; David J Young

Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
103 KB
Volume
38
Category
Article
ISSN
0040-4039

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✦ Synopsis

Treatment of acetals (1 and 2) and amino acetals (3-5) with either trifluoroacetic acid (TFA) or silica gel followed by tetraallyltin gave excellent yields of the corresponding homoallylic alcohols (68 -100%).

πŸ“œ SIMILAR VOLUMES

One-Pot Addition/Reduction Procedure for
One-Pot Addition/Reduction Procedure for the Synthesis of -Amino Alcohols from -Enamino Ketones
✍ Cristina Cimarelli; Sandra Giuli; Gianni Palmieri πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 English βš– 147 KB

## Abstract γ‐Amino alcohols **3** have been synthesized by the addition of organolithium reagents to β‐enamino ketones **1** followed by one‐pot reduction with sodium triacetoxyborohydride. The method allows the stereoselective synthesis of γ‐amino alcohols in which the hydroxy group is bonded to