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A simple method for the synthesis of specific [2H] and [3H]labelled methyl-hydroxylated derivatives of 7,12-dimethylbenz[a]anthracene

✍ Scribed by Peter P. Fu; Shen K. Yang

Publisher
John Wiley and Sons
Year
1979
Tongue
French
Weight
316 KB
Volume
16
Category
Article
ISSN
0022-2135

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✦ Synopsis

Specific [ ' H I and [ 3H] labelled methyl-hydroxylated derivatives of 7,12-dimethylbenz[a]anthracene (DMBA), 7-hydroxymethyl-12methylbenz[a]anthracene, 7-methyl-12-hydroxymethylbenz[a]anthracene, and 7,12-dihydroxymethylbenz[a]anthracene, were synthesized with good yield and high specific activity. method involved two simple steps; oxidation of the unlabelled methyl-hydroxylated DMBA to the corresponding forrnyl derivatives followed by reduction with either sodium borodeuteride or sodium borotriteride to yield the [ ' H I or [3H]labelled methyl-hydroxylated derivatives with the isotope specifically attached to benzylic carbons.

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