A simple method for the synthesis of 2′-O-alkylguanosine derivatives

✍ Scribed by Morten Grøtli; Mark Douglas; Barbro Beijer; Ramon Eritja; Brian Sproat

• Publisher: Elsevier Science
• Year: 1997
• Tongue: English
• Weight: 226 KB
• Volume: 7
• Category: Article
• ISSN: 0960-894X
• DOI: 10.1016/s0960-894x(97)00024-3

✦ Synopsis

A new synthetic route has been devised for the preparation of 2'-O-alkyl guanosine derivatives. Utilizing a strategy of minimal protection, the alkylation was performed on partly protected guanosine using an alkyl halide and a sterically hindered strong organic base.