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A simple method for the preparation of ▵3-cephalosporanic esters

✍ Scribed by Alberto Mangia; Angelo Scandroglio

Publisher
Elsevier Science
Year
1978
Tongue
French
Weight
114 KB
Volume
19
Category
Article
ISSN
0040-4039

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✦ Synopsis

A3-Cephalosporanic esters have been synthesized with the aim of obtaining orally active derivatives 1,2 or as a means for protecting the carboxylic funotion3 with easily removable blocking groups. This esterification is usually associated with double bond isomerization resulting in a mixture of A3-and A2-ester with consequent low yields of the former.

Dp to date only one general method of preparing pure A,esters, free of the respective A2-isomers, that is reaction of A-cephalosporanic acids with activated alkyl halides

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A simple preparative method for optically active glycidic esters
✍ Fumio Toda; Hideaki Takumi; Kenya Tanaka 📂 Article 📅 1995 🏛 Elsevier Science 🌐 English ⚖ 158 KB

Some optically active glycidic esters were prepared by resolution through inclusion complexation with a chiral host compound, (R,R)-(-)-trans-4,5-bis(hydroxydiphenylmethyl)-2,2dimethyl-1,3-dioxacyclopentane, and its derivatives. Optically active glycidic esters are useful synthon for various biolog