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A simple method for synthesis of amides and peptides through acyl chlorides : A rapid synthesis of thyrotropin releasing hormone

✍ Scribed by Fuyuhiko Matsuda; Shin Itoh; Noritaka Hattori; Mitsutoshi Yanagiya; Takeshi Matsumoto


Book ID
108372641
Publisher
Elsevier Science
Year
1985
Tongue
French
Weight
639 KB
Volume
41
Category
Article
ISSN
0040-4020

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## Abstract After over a decade of studies on aspartic protease inhibitors and water‐soluble prodrugs, we have been developing a novel method, since 2003, called ‘__O__‐acyl isopeptide method’, for the synthesis of peptides containing difficult sequences. With our recent discoveries of ‘__O__‐acyl