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A Simple Approach to Analyzing Protein Side-Chain Dynamics from13C NMR Relaxation Data

✍ Scribed by Vladimir A. Daragan; Kevin H. Mayo

Publisher: Elsevier Science
Year: 1998
Tongue: English
Weight: 181 KB
Volume: 130
Category: Article
ISSN: 1090-7807
DOI: 10.1006/jmre.1997.1310

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✦ Synopsis

A simple approach to deriving motional dynamics information of protein and peptide side chains by using 13C NMR relaxation data is presented. By using linear approximation of internal rotational correlation functions, simple equations for relating side-chain conformation, bond rotational amplitudes, and rotational correlation coefficients with different NMR relaxation parameters have been obtained. Auto- and cross-correlation spectral densities are considered, and it is shown that proton-coupled 13C NMR relaxation measurements allow detailed motional information to be obtained.

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