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A simple and efficient synthetic route to benzo[c]phenanthridines

✍ Scribed by Denis Séraphin; Michael A. Lynch; Olivier Duval

Publisher
Elsevier Science
Year
1995
Tongue
French
Weight
171 KB
Volume
36
Category
Article
ISSN
0040-4039

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Transformation of protoberberines into benzo[C]phenanthridines a novel and efficient synthesis of antitumor benzo[C]phenanthridine alkaloids, fagaronine and nitidine
✍ Miyoji Hanaoka; Hiroshi Yamagishi; Mari Marutani; Chisato Mukai 📂 Article 📅 1984 🏛 Elsevier Science 🌐 French ⚖ 259 KB

Antileukemic benzotclphenanthridine alkaloids, fagaronine (l(Y) and nitidine (1~) were synthesized from the corresponding protoberberines through C6-N bond fission and subsequent cyclization between C6 and Cl3 position of the protoberberines. Fully aromatized 2,3,8,9\_tetraoxygenated benzo[clphenant