A simple and efficient synthesis of goniothalesdiol A
β Scribed by Pallavi Thakur; Kumaraswamy Boyapelly; Raji Reddy Gurram; Rakeshwar Bandichhor; Khagga Mukkanti
- Book ID
- 116909643
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 378 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0957-4166
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π SIMILAR VOLUMES
The first total synthesis of Goniothalesdiol A, isolated from the stems of Goniothalamus amuyon (Annonaceae) is reported. The C2 stereocentre and C3/C4 syn diol were created by a Sharpless kinetic resolution followed by acetonide formation. The tetrahydropyran ring was formed and the C6 stereocentre
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## Abstract The stereocontrolled synthesis of goniothalesdiol A, a dihydroxylated tetrahydropyran compound, has been accomplished using Dβribose as chiral precursor. The key steps involved are aryl __Grignard__ reaction, stereoselective alkoxyβdirected keto reduction, and intramolecular oxyβ__Micha