✦ LIBER ✦

A simple and efficient synthesis of [3H]cholesteryl 14-methylhexadecanoate

✍ Scribed by O. Helmich; J. Hradec

Book ID: 102374604
Publisher: John Wiley and Sons
Year: 1981
Tongue: French
Weight: 321 KB
Volume: 18
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580180517

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✦ Synopsis

Abstract

The reaction of labelled cholesterol with a large excess of freshly prepared 14‐methylhexadecanoyl chloride in a simple glass apparatus was used for the synthesis of [^3^H]cholesteryl 14‐methylhexadecanoate in microgram amounts. After purification of the crude product by thin‐layer chromatography, the purity of the final preparation was better than 98% as checked by gas‐liquid and high‐pressure liquid chromatography. On average 90% of the input radioactivity was present in the ester. The same technique was also used for the preparation of [^14^C]cholesteryl 14‐methylhexadecanoate and [^3^H] or [^14^C]cholesteryl laurate, myristate, palmitate, margarate and stearate with similar yields. All these preparations were found suitable for biochemical studies.

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