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A "Silent" Polymorphism in the MDR1 Gene Changes Substrate Specificity

✍ Scribed by Kimchi-Sarfaty, C.; Oh, J. M.; Kim, I.-W.; Sauna, Z. E.; Calcagno, A. M.; Ambudkar, S. V.; Gottesman, M. M.

Book ID
121672061
Publisher
American Association for the Advancement of Science
Year
2007
Tongue
English
Weight
509 KB
Volume
315
Category
Article
ISSN
0036-8075

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A "Silent" Polymorphism in the MDR1 Gene
A "Silent" Polymorphism in the MDR1 Gene Changes Substrate Specificity
✍ Kimchi-Sarfaty, C.; Oh, J. M.; Kim, I.-W.; Sauna, Z. E.; Calcagno, A. M.; Ambudk πŸ“‚ Article πŸ“… 2007 πŸ› American Association for the Advancement of Scienc 🌐 English βš– 509 KB

Synonymous single-nucleotide polymorphisms (SNPs) do not produce altered coding sequences, and therefore they are not expected to change the function of the protein in which they occur. We report that a synonymous SNP in the __Multidrug Resistance__ 1 ( __MDR__ 1) gene, part of a haplotype previousl