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A Signaling Pathway Mediating Downregulation of BCL6 in Germinal Center B Cells Is Blocked by BCL6 Gene Alterations in B Cell Lymphoma

โœ Scribed by Masumichi Saito; Jie Gao; Katia Basso; Yukiko Kitagawa; Paula M. Smith; Govind Bhagat; Alessandra Pernis; Laura Pasqualucci; Riccardo Dalla-Favera


Book ID
113523773
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
34 KB
Volume
12
Category
Article
ISSN
1535-6108

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## Abstract ## BACKGROUND In Western populations, rearrangement of the __BCL__โ€6 gene can be identified in 20โ€“40% of patients with diffuse large Bโ€cell lymphoma (DLBCL). Analysis of the __BCL__โ€6 gene has revealed the presence of point mutations or small deletions in 70% of DLBCL tumors; however,