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A Sibship Test for Linkage in the Presence of Association: The Sib Transmission/Disequilibrium Test

✍ Scribed by Richard S. Spielman; Warren J. Ewens

Book ID
117852290
Publisher
American Society of Human Genetics
Year
1998
Tongue
English
Weight
121 KB
Volume
62
Category
Article
ISSN
0002-9297

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Family-based association tests such as the transmission-disequilibrium test (TDT), which compare alleles transmitted and non-transmitted from parents to affected offspring, are widely used to detect the role of genetic risk factors in diseases. These methods have the advantage of being robust to pop