## Abstract The power of transmission/disequilibrium tests (TDTs) for detecting disease susceptibility loci is expected to be influenced by population admixture through its impact on the degree of linkage disequilibrium (LD) between the genetic marker and the DSL. However, few studies have been don
The power of the Transmission Disequilibrium Test in the presence of population stratification
✍ Scribed by Sebro, Ronnie; Rogus, John J
- Book ID
- 109849403
- Publisher
- Nature Publishing Group
- Year
- 2010
- Tongue
- English
- Weight
- 345 KB
- Volume
- 18
- Category
- Article
- ISSN
- 1018-4813
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Family-based association tests such as the transmission-disequilibrium test (TDT), which compare alleles transmitted and non-transmitted from parents to affected offspring, are widely used to detect the role of genetic risk factors in diseases. These methods have the advantage of being robust to pop
Due in part to an influential paper by Risch and Merikangas [(1996) Science 273:1516-1517], which suggested that disequilibrium tests would have greater power to detect genes of small effect than would linkage tests, interest in the use of the Transmission Disequilibrium Test (TDT) as an analysis to
## Abstract The aim of this study is to compare the power of the transmission disequilibrium test (TDT) to that of the identity‐by‐descent (IBD) distribution test. The relative powers of these tests depend both on the underlying genetic model and on the available family data. Families with two affe
## Abstract Allison ([1997] Am. J. Hum. Genet. 60:676–690) proposed four versions of the transmission‐disequilibrium test (TDT) for quantitative traits when there is __extreme‐threshold sampling__, i.e., the trios having an offspring trait value between a priori defined thresholds are excluded from