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A Short Synthesis of the A/B Ring Systems of the Pacific Ciguatoxins P-CTX-3C and Dihydroxy-P-CTX-3C

โœ Scribed by Eriksson, Ludvig; Guy, Sharon; Perlmutter, Patrick; Lewis, Richard


Book ID
125967035
Publisher
American Chemical Society
Year
1999
Tongue
English
Weight
109 KB
Volume
64
Category
Article
ISSN
0022-3263

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Convergent synthesis of the EFGH ring fr
โœ Hiroto Imai; Hisatoshi Uehara; Masayuki Inoue; Hiroki Oguri; Tohru Oishi; Masahi ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 95 KB

A stereoselective synthesis of the EFGH ring fragment of ciguatoxin CTX3C has been achieved through: (i) selective cleavage of a dioxepane acetal C O bond; (ii) radical cyclization to form the oxepane G ring; and (iii) chemoselective ring-closing metathesis of a triene yielding the hexahydrooxonin F