Convergent synthesis of the EFGH ring fr
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Hiroto Imai; Hisatoshi Uehara; Masayuki Inoue; Hiroki Oguri; Tohru Oishi; Masahi
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Article
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2001
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Elsevier Science
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French
⚖ 95 KB
A stereoselective synthesis of the EFGH ring fragment of ciguatoxin CTX3C has been achieved through: (i) selective cleavage of a dioxepane acetal C O bond; (ii) radical cyclization to form the oxepane G ring; and (iii) chemoselective ring-closing metathesis of a triene yielding the hexahydrooxonin F