A Short Synthesis of Staurosporinone (K-252c) (V).
β Scribed by Susana P Gaudencio; Maria M. M. Santos; Ana M. Lobo; Sundaresan Prabhakar
- Publisher
- John Wiley and Sons
- Year
- 2003
- Weight
- 92 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0931-7597
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Stereocontrolled Total Synthesis of (+)-K252a. -The cycloglycosidic indolocarbazole alkaloid (I) shows strong PKC inhibitory activity. A linear 23-step sequence starting from indole-3-acetic acid is developed for the synthesis of (I) in 10% overall yield. The known deoxyfuranose derivative (II) is u
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