A four-step synthesis of the ardeemin framework by starting from N-2-aminobenzoyl-a-amino esters is described. In the last step, the acid promoted cyclization of the 1,4-anti-4-alkyl-1-(3-indolylmethyl)-2,4-dihydro-1H-pyrazino[2,1-b]quinazoline-3,6-diones occurs irreversible and stereocontrolled.
A Short Synthesis of De-“Prenyl”-Ardeemin.
✍ Scribed by Fernando Hernandez; Carmen Avendano; Monica Soellhuber
- Publisher
- John Wiley and Sons
- Year
- 2003
- Weight
- 77 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0931-7597
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