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A short synthesis of bicyclic sugar pyrimidine nucleosides from C-glycosides
β Scribed by Jonghoon Oh; Chung Ryul Lee; Keun Ho Chun
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- French
- Weight
- 57 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0040-4039
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Nucleophilic ring-opening and rearrangement reaction of a furanopyrimidine nucleoside with anhydrous hydrazine provided a novel, 6,6-bicyclic pyrimidopyridazin-7-one nucleoside (dH, 4), whose structure was confirmed by X-ray crystallography. This novel nucleoside was converted to its 5%-triphosphate
In order to obtain rigidity within the sugar moiety of nucleosides, some bicyclic pyrimidine nucleoside analogues were synthesized starting from cyclopentanone. The C-3' is fused to C-4' via a propylene linker in order to obtain a [3.3.0]-bicyclic ring system wherein the sugar moiety should be restr
Increasing research has focused on examining the similarity between pyridopyrimidines and pyrimido [2,3-d]pyrazines, also referred to as pteridines [1]. Significant antitumor activity against Walker muscular carcinosarcoma in rats has been demonstrated for 4-oxopyrido [2,3-d]pyrimidine (A) and 2,4-d