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A short stereoselective synthesis of cis- and trans-4-hydroxyl-L-proline

✍ Scribed by Mehlf�hrer, Michaela; Berner, Heinz; Thirring, Klaus


Book ID
118016459
Publisher
The Royal Society of Chemistry
Year
1994
Tongue
English
Weight
143 KB
Volume
11
Category
Article
ISSN
0022-4936

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Efficient and stereoselective synthesis
✍ Junyi Zhang; Wei Wang; Chiyi Xiong; Victor J. Hruby 📂 Article 📅 2003 🏛 Elsevier Science 🌐 French ⚖ 222 KB

A series of novel cis-4-substituted proline analogues were designed and synthesized. Highly stereoselective alkylations at the g-position of glutamic ester 2 were achieved, followed by reduction, mesylation, and cyclization to afford the title compounds 1 in good yields and high diastereoselectivity