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A short history of thalidomide embryopathy

✍ Scribed by Lenz, W.

Book ID
118286520
Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
821 KB
Volume
38
Category
Article
ISSN
0040-3709

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πŸ“œ SIMILAR VOLUMES

Hypothesis: Thalidomide embryopathy?prop
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✍ Stephens, Trent D.; Fillmore, Bradley J. πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 98 KB πŸ‘ 1 views

We propose that thalidomide affects the following pathway during limb development: Growth factors (FGF-2 and IGF-I) attach to receptors on limb bud mesenchymal cells and initiate some second messenger system (perhaps SP-1), which activates ␣v and ␀3 integrin subunit genes. The resulting ␣v ␀3 integr

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## Abstract Thalidomide is the best known human teratogen. Although withdrawn from the market in 1961, thalidomide was remarketed after 1965 in several countries, for the treatment of erythema nodosum leprosum. Thalidomide has a potent immunomodulatory property and has now a number of approved and