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A short chemoenzymatic synthesis of (+)-multifidene and (+)-viridiene

✍ Scribed by Jacques Lebreton; Véronique Alphand; Roland Furstoss


Book ID
103405497
Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
231 KB
Volume
37
Category
Article
ISSN
0040-4039

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## Abstract The absolute configurations of the two algal pheromones multifidene **1** and viridiene **2** were determined as (+)‐(3__S__, 4__S__)‐3‐[(__Z__)‐1‐butenyl]‐4‐vinylcyclopentene and (+)‐(3__R__, 4__S__)‐3‐[(1__Z__)‐1, 3‐butadienyl]‐4‐vinylcyclopentene, respectively. The strategy involves

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## Abstract (+)‐Multifidence ((+)‐1) has been synthesized starting from (__R__)‐(cyclopent‐2‐enyl)methanol ((+)‐2) __via__ its chloroformate 4, Co‐mediated radical cyclization reaction to the lactone (+)‐6, and introduction of the olefinic side chains.

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