✦ LIBER ✦

A short and highly stereoselective synthesis of α-(2-aminothiazolyl)-C-nucleosides

✍ Scribed by Jean-Michel Navarre; Dominique Guianvarc'h; Audrey Farese-Di Giorgio; Roger Condom; Rachid Benhida

Publisher: Elsevier Science
Year: 2003
Tongue: French
Weight: 113 KB
Volume: 44
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(03)00159-x

No coin nor oath required. For personal study only.

✦ Synopsis

A short route to novel a-(2-aminothiazolyl)-C-nucleosides has been developed. The key step was the high diastereoselective reduction of the hemiacetal intermediates using L-Selectride, which afforded the corresponding R-diols in quantitative yields. These diols were converted, after C4-C1 ring closure and protecting groups cleavage, to their corresponding free a-C-nucleosides.

📜 SIMILAR VOLUMES

A Short and Highly Stereoselective Synth

A Short and Highly Stereoselective Synthesis of α-(2-Aminothiazolyl)-C-nucleosides.

✍ Jean-Michel Navarre; Dominique Guianvarc'h; Audrey Farese-Di Giorgio; Roger Cond 📂 Article 📅 2003 🏛 John Wiley and Sons ⚖ 22 KB 👁 1 views

## Abstract For Abstract see ChemInform Abstract in Full Text.

A Short and Highly Stereoselective Synth

A Short and Highly Stereoselective Synthesis of Cerebrosterol

✍ Dong-Hiri Zhang; Xiang-Dong Zhou; Wei-Shan Zhou 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 261 KB 👁 2 views

A short stereoselective synthesis of (±)

A short stereoselective synthesis of (±)-litsenolides C1 and C2.

✍ Pierre Barbier; Claude Benezra 📂 Article 📅 1982 🏛 Elsevier Science 🌐 French ⚖ 200 KB

A five-.step synthesis of the above substances from ethy2 phenylthioacetate and I-bromotetradecane is described.

A Short and Efficient Synthesis of 2′-De

A Short and Efficient Synthesis of 2′-Deoxybenzo- and Pyridoimidazole C-Nucleosides.

✍ Mohamed Jazouli; Dominique Guianvarc'h; Mohamed Soufiaoui; Khalid Bougrin; Pierr 📂 Article 📅 2003 🏛 John Wiley and Sons ⚖ 125 KB 👁 1 views

A short and efficient synthesis of 2′-de

A short and efficient synthesis of 2′-deoxybenzo- and pyridoimidazole C-nucleosides

✍ Mohamed Jazouli; Dominique Guianvarc'h; Mohamed Soufiaoui; Khalid Bougrin; Pierr 📂 Article 📅 2003 🏛 Elsevier Science 🌐 French ⚖ 207 KB

A Short and Highly Stereoselective Synth

A Short and Highly Stereoselective Synthesis of Squalamine from Methyl Chenodeoxycholanate

✍ Zhang Dong-Hui; Cai Feng; Zhou Xiang-Dong; Zhou Wei-Shan 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 76 KB 👁 2 views

A short and highly stereoselective synthesis of squalamine (1) was accomplished in 9 steps from easily available methyl chenodeoxycholanate (2). The advanced intermediate 7α,24R-dihydroxy-cholestan-3-one (9) was synthesized by using improved dehydrogenation of 4 followed by conjugate reduction and e