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A short and efficient synthesis of (−)-methyl 8-epi-nonactate

✍ Scribed by Byeang Hyean Kim; Ju Young Lee

Book ID
103406301
Publisher
Elsevier Science
Year
1993
Tongue
French
Weight
122 KB
Volume
34
Category
Article
ISSN
0040-4039

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Enantioselectiw routes to (+)-methyl nonactate (2) and (-)-m&y1 8-epi-nonactate (3) are described. The cornerstone of this synrktic strategy is a combination of asymmetric silyl tdtro~re cycloaddition and asymmetric reduction, which provides rhe key syn-1 &ii01 intermediate 4. ## Nonactin (1) is an