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A series of diarylsubstituted oximes as potential substrate for new aldose reductase inhibitors

✍ Scribed by Dietmar Rakowitz; Gottfried Heinisch; Peter Lukavsky; Sigrid Kiendler; Cornelia Trenkwalder; Daniela Barlocco; Giulio Rastelli; Luca Costantino

Publisher: Journal of Heterocyclic Chemistry
Year: 2000
Tongue: English
Weight: 491 KB
Volume: 37
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570370511

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✦ Synopsis

Abstract

In the course of our research aimed at the discovery of new compounds acting as aldose reductase inhibitors, we tested a series of some (E)‐ and (Z)‐ω‐[[(aryldiazinylmethylene)amino]oxy]alkanoic acids, which were found to have moderate in vitro inhibitory activity. On this basis we have now prepared several new derivatives modified both at the length of the chain and at its terminal carboxylic group, together with compounds carrying various substituents at the phenyl ring. This paper describes their synthesis and biological properties.

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