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Hydrazonoyl Halides as Precursors for New Fused Heterocycles of 5α-Reductase Inhibitors

✍ Scribed by Thoraya A. Farghaly; Sobhi M. Gomha; Eman M. H. Abbas; Mohamed M. Abdalla

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
159 KB
Volume
345
Category
Article
ISSN
0365-6233

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✦ Synopsis

Abstract

A new series of benzo[6,7]cyclohepta[1,2‐d]triazolo[4,3‐a]pyrimidines 8a–l was synthesized via reaction of heterocyclic thione 4 or its methyl derivatives 10 with hydrazonoyl halides 5a–l. Also, reaction of compound 4 with a mixture of chloroacetic acid and aromatic aldehyde derivatives gave benzo[6,7]cyclohepta[1,2‐d]thiazolo[3,2‐a]pyrimidin‐3‐ones 12–14. The microanalyses and spectral data of the synthesized compounds are in full agreement with their molecular structure. All the newly synthesized products were screened against 5α‐reductase and showed activities with good ED~50~ for all compounds.

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