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A Serendipitous Discovery: Nickel Catalyst for the Cycloaddition of Diynes with Unactivated Nitriles

✍ Scribed by Puneet Kumar; Simon Prescher; Prof. Dr. Janis Louie


Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
365 KB
Volume
123
Category
Article
ISSN
0044-8249

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Ir(cod)Cl] 2 combined with dppe was found to be a new and efficient catalyst for [2+2+2] cycloaddition. Dimethyl dipropargylmalonate reacted with 1-hexyne in the presence of a catalytic amount of [Ir(cod)Cl] 2 combined with dppe at room temperature in 20 min to give an indane derivative in 84% yield