✦ LIBER ✦

A sequential double-blind controlled study of moclobemide and mianserin in elderly depressed patients

✍ Scribed by John Tiller; Dr Kay Maguire; Brian Davies

Publisher: John Wiley and Sons
Year: 1990
Tongue: English
Weight: 498 KB
Volume: 5
Category: Article
ISSN: 0885-6230
DOI: 10.1002/gps.930050309

No coin nor oath required. For personal study only.

✦ Synopsis

Moclobemide was compared with mianserin in a double-blind controlled study in elderly depressed patients. Sequential analysis of 1 1 pairs of patients found no significant difference between the drugs at the week 8 analysis. Unpaired comparison of the 26 patients completing four weeks' treatment also showed no significant difference between the two drugs. Both drugs significantly reduced Hamilton and Carroll depression rating scores. A separate analysis of the 20 patients completing eight weeks' treatment showed that both drugs produced significant decreases in Hamilton and Carroll depression ratings with no significant difference between the two drugs for depression scores at either week 4 or 8. Side-effects were minimal, with the most severe emergent side-effects for moclobemide being sleep disturbance, blurred vision and dry mouth. KEY worn-Moclobemide, mianserin, elderly, depression.

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