✦ LIBER ✦

Venlafaxine versus nortriptyline in the treatment of elderly depressed inpatients: a randomised, double-blind, controlled trial

✍ Scribed by Rob M. Kok; Willem A. Nolen; Thea J. Heeren

Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 125 KB
Volume: 22
Category: Article
ISSN: 0885-6230
DOI: 10.1002/gps.1823

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Background

The majority of the trials in the elderly are outpatient trials which excluded psychotic patients and patients with common comorbid physical disorders. Consequently information is lacking about the more complex cases of elderly depressed patients, as found in inpatient wards.

Objective

To evaluate the effectiveness of two antidepressants, venlafaxine and nortriptyline, in a clinically representative sample of elderly depressed inpatients.

Method

A 12‐week, double blind, randomised, controlled trial in 81 elderly inpatients from one centre. All patients fulfilled DSM‐IV criteria for major depression and were assessed using the Montgomery Åsberg Depression Rating Scale, the Hamilton Depression Rating Scale, the Geriatric Depression Scale, the Clinical Global Improvement and the Symptom, sign, and Side‐effect Checklist.

Results

Overall, remission was achieved by 26 (32.1%) of the patients. There was no statistically significant difference in the number of patients achieving remission on the MADRS between venlafaxine (11 out of 40 patients) and nortriptyline (15 out of 41 patients; p = 0.381) or in any of the secondary outcome variables. The number and severity of side‐effects was not statistically different between both treatment groups and most side effects were mild or moderate in intensity.

Conclusions

📜 SIMILAR VOLUMES

Double-blind controlled withdrawal of th

Double-blind controlled withdrawal of thioridazine treatment in elderly female inpatients with senile dementia

✍ D. J. Findlay; J. Sharma; J. McEwen; B. R. Ballinger; W. J. MaClennan; A. M. McH 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 English ⚖ 430 KB 👁 1 views

Thirty-six female inpatients with a clinical diagnosis of senile dementia, Alzheimer type, were entered into a doubleblind withdrawal of their established thioridazine. Over a four-week period there were no significant differences between the two study groups in terms of cognitive function, behaviou

Efficacy and tolerability of venlafaxine

Efficacy and tolerability of venlafaxine in geriatric outpatients with major depression: a double-blind, randomised 6-month comparative trial with citalopram

✍ Per Allard; Lars Gram; Kristina Timdahl; Kirsten Behnke; Martin Hanson; Jesper S 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 85 KB 👁 1 views

## Abstract ## Background The objectives of the study were to compare efficacy and tolerability of venlafaxine ER 75–150 mg/day with that of citalopram 10–20 mg/day in elderly patients with major depression according to DSM‐IV criteria. ## Methods A randomised, double‐blind, parallel group 6‐mon

A double-blind, placebo-controlled asses

A double-blind, placebo-controlled assessment of nortriptyline's side-effects during 3-year maintenance treatment in elderly patients with recurrent major depression

✍ Rory L. Marraccini; Charles F. Reynolds III; Patricia R. Houck; Mark D. Miller; 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 77 KB 👁 2 views

The authors assessed the severity of nortriptyline's side-effects in older patients with recurrent major depression during placebo-controlled, double-blind maintenance therapy. Data were from 37 patients completing 2-3 years of maintenance therapy; 29 were on nortriptyline and eight were on placebo.

A double-blind placebo-controlled trial

A double-blind placebo-controlled trial of milnacipran in the treatment of fibromyalgia

✍ Olivier Vitton; Michael Gendreau; Judy Gendreau; Jay Kranzler; Srinivas G. Rao 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 195 KB

Fibromyalgia syndrome is a systemic disorder of widespread pain which is thought to result from abnormal pain processing within the central nervous system. There are no currently approved treatments for this indication. Antidepressants appear, however, to be effective, especially those with an actio

Randomised, double-blind, placebo-contro

Randomised, double-blind, placebo-controlled trial to assess the potential of cannabinoid receptor stimulation in the treatment of dystonia

✍ Susan H. Fox; Mark Kellett; A. Peter Moore; Alan R. Crossman; Jonathan M. Brotch 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 149 KB

## Abstract Cannabis may have medicinal uses in a variety of diseases. The neural mechanisms underlying dystonia involve abnormalities within the basal ganglia—in particular, overactivity of the lateral globus pallidus (GPl). Cannabinoid receptors are located presynaptically on GABA terminals withi

Clinical trial of adjunctive celecoxib t

Clinical trial of adjunctive celecoxib treatment in patients with major depression: a double blind and placebo controlled trial

✍ Shahin Akhondzadeh; Sara Jafari; Firoozeh Raisi; Abbas Ali Nasehi; Aboulfazl Gho 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 91 KB 👁 2 views