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A Sensitive and Selective GC–MS Method for Analysis of Process-Related Genotoxic Impurities in Atenolol

✍ Scribed by Yogeshwar Reddy Mamilla; Kista Reddy Chetyala; Ramesh Venna; Raju Gajjela; Kishore Katragadda; Saravanan Govindasamy; Suryanarayana Mulukutla; Debashish Datta


Book ID
111791931
Publisher
Springer
Year
2010
Tongue
English
Weight
263 KB
Volume
71
Category
Article
ISSN
0009-5893

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## Abstract A highly sensitive simultaneous quantitative method for a cassette cold‐microdosing study on celiprolol and atenolol was developed with liquid chromatography–tandem mass spectrometry. The method utilizes a combination of solid‐phase extraction (SPE) with strong cation exchange (SCX) car