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A secondary kinetic isotope effect in conformational racemization

โœ Scribed by Kurt Mislow; Edward Simon; Harvey B. Hopps

Publisher
Elsevier Science
Year
1962
Tongue
French
Weight
176 KB
Volume
3
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

RECENT studies of secondary kinetic isotope effects have focussed on reactions which involve bond making and breaking at or near the site of isotopic substitution. We have now observed a mass effect in a purely conformational change: the racemization of diketones I and II. In connection with our work on doubly bridged biphenyls 2 we had occasion to prepare I, m. p. 223-224' (under nitrogen), II Grateful acknowledgment is made to the donors of the Petroleum Research Fund, administered by the American Chemical Society, for the partial support of this research, and to the Alfred P. Sloan Foundation for fellowship support (K. M.).

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