Linkage data, using the polymorphic markers 52A (DXS51), F9, 4D-8 (DXS98), and St14 (DXS52), are presented from 14 fragile X pedigrees and from 7 normal pedigrees derived from the collection of the Centre d't~tude du Polymorphisme Humaine. A multipoint linkage analysis indicates that the most probab
A search for linkage in families with fragile sites
โ Scribed by J. C. Mulley; Catherine Nicholls; G. R. Sutherland
- Book ID
- 104704794
- Publisher
- Springer
- Year
- 1983
- Tongue
- English
- Weight
- 217 KB
- Volume
- 65
- Category
- Article
- ISSN
- 0340-6717
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๐ SIMILAR VOLUMES
We report an extended family in which two brothers with a fragile X chromosome are mentally retarded while a third brother with the fragile site is both phenotypically and mentally normal. The study of six probes detecting restriction fragment length polymorphisms on either sides of the fragile site
We present clinical, cytogenetic, and linkage data of four DNA probes from the terminal long arm of the X chromosome in ten new families with fragile X syndrome. A prior/posterior method of multipoint linkage analysis is employed to combine these results with published data to refine the linkage map