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Intragenic probe used for diagnostics in fragile X families

✍ Scribed by Verkerk, Annemieke J. M. H. ;De Vries, Bert B. A. ;Niermeijer, Martinus F. ;Fu, Ying-Hui ;Nelson, David L. ;Warren, Stephen T. ;Majoor-Krakauer, Danielle F. ;Halley, Dicky J. J. ;Oostra, Ben A.

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
377 KB
Volume
43
Category
Article
ISSN
0148-7299

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## Abstract A model for the transmission of the CGG repeat sequence associated with the fragile‐X dynamic mutation in the FMR1 gene is developed. The model incorporates both haplotype and family effects on the expansion rate of the sequence. The resulting random effects model is fitted to new data,