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A search for human T-cell leukemia virus type I in the lesions of patients with tropical spastic paraparesis and polymyositis

✍ Scribed by Frédéric Tangy; Jean-Claude Vernant; Laurent Coscoy; Marlène Ossondo; RéMi Bellance; Vladimir Zaninovic; Luis Cartier; Michel Brahic; Dr Simona Ozden

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
772 KB
Volume
38
Category
Article
ISSN
0364-5134

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✦ Synopsis

Abstract

We searched for the presence of human T‐cell leukemia virus type I (HTLV‐I) sequences in central nervous system and muscle lesions of 3 patients with tropical spastic paraparesis/HTLV‐I—associated myelopathy (TSP/HAM) and 3 patients with HTLV‐I—associated polymyositis. Proviral DNA coding for the Tax protein was found by polymerase chain reaction amplification in DNA extracted form lesions of every patient with TSP/HAM or HTLV‐I—associated polymyositis. In contrast, viral RNA was found occasionally by in situ hybridization in muscle lesions of some patients with polymyositis, but was never found in central nervous system lesions of TSP/HAM patients.

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