Asymmetric induction in the 1,7 ring clo
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Alexander J. Blake; Mervyn Harding; John T. Sharp
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Article
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1988
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Elsevier Science
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French
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In the cyclisation of the diazo-compound (7) to give the diastereomerit pair of lH-2,3\_benzodiazepines (8) and ( 9), alkoxy groups, when present as the medium sized group M, show the opposite effect in promoting face selectivity to that of alkyl groups and the alkoxide ion. Thus when M=OMe the ( 8