✦ LIBER ✦
Asymmetric induction in the 1,7 ring closure of diene-conjugated diazo-compounds: a route to chiral 1h-2,3-benzodiazepines
✍ Scribed by Alexander J. Blake; Mervyn Harding; John T. Sharp
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- French
- Weight
- 248 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
In the cyclisation of the diazo-compound (7) to give the diastereomerit pair of lH-2,3_benzodiazepines (8) and ( 9), alkoxy groups, when present as the medium sized group M, show the opposite effect in promoting face selectivity to that of alkyl groups and the alkoxide ion.
Thus when M=OMe the ( 8):(g) ratio is 92:8 while in contrast when M=O-the ratio is 15:85.
Studies on asymmetric induction have embraced many types of reaction