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A role for sphingosine kinase 1 in dextran sulfate sodium-induced colitis

✍ Scribed by Snider, Ashley J. (author);Kawamori, Toshihiko (author);Bradshaw, Sarah G. (author);Orr, K Alexa (author);Gilkeson, Gary S. (author);Hannun, Yusuf A. (author);Obeid, Lina M. (author)

Book ID: 120809289
Publisher: Wiley
Year: 2008
Tongue: English
Weight: 692 KB
Volume: 23
Category: Article
ISSN: 0892-6638
DOI: 10.1096/fj.08-118109

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## Background: In this study we determined the consequence of the absence of each tnf receptor, tnfr1 or tnfr2, in the dextran sulfate sodium (dss) model of colitis. ## Methods: Wildtype (wt), tnfr1(-/-) and tnfr2(-/-) mice were fed 3% w/v dss in drinking water for 5 days followed by 2 (day 7) or