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A Role for Presenilin-1 in Nuclear Accumulation of Ire1 Fragments and Induction of the Mammalian Unfolded Protein Response

✍ Scribed by Maho Niwa; Carmela Sidrauski; Randal J Kaufman; Peter Walter

Book ID: 117268421
Publisher: Elsevier Science
Year: 1999
Tongue: English
Weight: 409 KB
Volume: 99
Category: Article
ISSN: 0092-8674
DOI: 10.1016/s0092-8674(00)81667-0

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## Abstract BAG‐1 (Bcl‐2 associated athanogene‐1) is a multifunctional protein, linking cell proliferation, cell death, protein folding, and cell stress. In vivo, BAG‐1 is expressed in growth plate and articular cartilage, and the expression of BAG‐1 is decreased with aging. Chondrocytes respond to