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A role for Myc in facilitating transcription activation by E2F1

✍ Scribed by Leung, J Y; Ehmann, G L; Giangrande, P H; Nevins, J R

Book ID: 109970846
Publisher: Nature Publishing Group
Year: 2008
Tongue: English
Weight: 290 KB
Volume: 27
Category: Article
ISSN: 0950-9232
DOI: 10.1038/onc.2008.55

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## Abstract E2F1, a member of the E2F family of transcription factors, plays a critical role in controlling both cell cycle progression and apoptotic cell death in response to DNA damage and oncogene activation. Following genotoxic stresses, E2F1 protein is stabilized by phosphorylation and acetyla