## Abstract The integrin ฮฑvฮฒ3 mediates cellโmatrix interactions. Vitaxinยฎ, a humanized monoclonal antibody that blocks human and rabbit ฮฑvฮฒ3 integrins, is in clinical trials for metastatic melanoma and prostate cancer. ฮฑvฮฒ3 is the predominant integrin on osteoclasts, the cells responsible for bone
โฆ LIBER โฆ
A role for ezrin in a neglected metastatic tumor function
โ Scribed by Stefano Fais
- Book ID
- 116757849
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 89 KB
- Volume
- 10
- Category
- Article
- ISSN
- 1471-4914
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## Abstract __ARID1A__ is located in 1p36.11, a region frequently deleted in human cancers. Using a novel method to screen for tumorigenic cDNA sequences, we have identified __ARID1A__ as a presumptive tumor suppressor gene. The transforming __ARID1A__ sequence was an antisense cDNA, and was the pr