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A role for c-myc in DNA damage-induced apoptosis in a human TP53-mutant small-cell lung cancer cell line

✍ Scribed by R Supino; P Perego; L Gatti; C Caserini; C Leonetti; M Colantuono; V Zuco; N Carenini; G Zupi; F Zunino


Book ID
117657366
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
310 KB
Volume
37
Category
Article
ISSN
0959-8049

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## Small -cell-lung-cancer (SCLC) is characterized by rapid development of resistance to cytotoxic agents, such as cisplatin (cDDP) and anthracyclines. c-myc over-expression is one of the reported genetic alterations in this tumor. Amplification of the c-myc gene in this and other cancers is often