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A robust and quantitative method for tracking liposome contents after intravenous administration

✍ Scribed by Kohli, Aditya G.; Kieler-Ferguson, Heidi M.; Chan, Darren; Szoka, Francis C.

Book ID
121728733
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
703 KB
Volume
176
Category
Article
ISSN
0168-3659

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An HPLC assay has been developed to measure 4-aminopyridine (4-AP) in guinea pig plasma. For the assay, all plasma samples (50 FL) were microfiltered following the addition of an internal standard (3,4-diaminopyridine). Filtrates (10 pL) were directly injected into a spherical silica column (100~2.