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A review of the therapeutic agents used in the management of polycythaemia vera

✍ Scribed by Mary Frances McMullin

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
136 KB
Volume
25
Category
Article
ISSN
0278-0232

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✦ Synopsis

Abstract

The acquired clonal disorder Polycythaemia Vera leads to increased erythropoiesis, myelopoiesis and megakaryopoeisis. These anomalies result in an increased incidence of thromboembolic events, transformation to acute leukaemia and myelofibrosis. Treatments which aim to reduce the event rate may increase anaemia but may also affect the rate of complications. This paper reviews the evidence for the treatments which have been used in the management of the disorders over a 50 plus year period. Assessment of this evidence and its limitations form the basis for the current suggested management plans. Copyright Β© 2007 John Wiley & Sons, Ltd.

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