Background. In a previous Phase I1 trial, the authors showed that a weekly continuous infusion of 5-fluorouracil (5-FU) at a dose of 3.5 g/mz for 48 hours is an active treatment for advanced colorectal cancer. The overall response rate was 38.5%, and the median survival was 12 months. These data wer
✦ LIBER ✦
A review of GERCOD trials of bimonthly leucovorin plus 5-fluorouracil 48-h continuous infusion in advanced colorectal cancer: evolution of a Regimen
✍ Scribed by A de Gramont; C Louvet; T André; C Tournigand; M Krulik
- Book ID
- 117664064
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 200 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0959-8049
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## BACKGROUND. Reports of in vitro experiments in colorectal carcinoma cells suggest that prolonged cellular exposure to 5-fluorouracil (5-FU) combined with relatively low concentrations of leucovorin (LV) provides optimal enhancement of 5-FU efficacy. In this study, a simplified regimen of weekly