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A reversible monoamine oxidase inhibitor, toloxatone: Structural and electronic properties

✍ Scribed by F Moureau; J Wouters; DP Vercauteren; S Collin; G Evrard; F Durant; F Ducrey; JJ Koenig; FX Jarreau


Book ID
103629654
Publisher
Elsevier Science
Year
1992
Tongue
French
Weight
894 KB
Volume
27
Category
Article
ISSN
0223-5234

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Biochemical and pharmacologic properties
✍ Helen L. White; Philip W. Scates; Jane C. Harrelson; Thomas E. Johnson; Ron M. N πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 149 KB πŸ‘ 1 views

## 2614W94 [3-(1-trifluoromethyl) ethoxyphenoxathiin 10,10-dioxide] is a selective, reversible inhibitor of monoamine oxidase-A with a competitive mechanism of inhibition and a K i value of 1.6 nM with serotonin as substrate. In pretreated rats, the ED 50 value after single oral dosing was 1.7 mg/